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A. A. Up-regulation of p21 and p53 were detected in TPD52-overexpressed HepG2 and Bel7402 cells. But the expression of MDM2, P-GSK-3β and BCL2 were decreased in TPD52-overexpressed HepG2 and Bel7402 cells. B. Down-regulation of p21 and p53 were detected in TPD52-knockdown HepG2 and Bel7402 cells. However, the expression of MDM2, P-GSK-3β and BCL2 were increased in TPD52-knockdown HepG2 and Bel7402 cells.
