Table 2. Univariate and multivariate analysis of overall survival in HCC.

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI	p value	HR	95% CI	P value
Age	0.780	0.507-1.201	0.259
Gender	1.050	0.625-1.764	0.853
HBV	1.250	0.646-2.417	0.508
Tumor size	1.527	1.003-2.324	0.048*	1.340	0.873-2.058	0.181
Tumor number	1.731	1.067-2.811	0.026*	1.627	0.997-2.654	0.051
Tumor encapsulation	1.161	0.888-1.517	0.276
TNM stage	2.210	1.446-3.678	<0.001*	1.708	1.085-2.689	0.021*
Liver cirrhosis	1.080	0.642-1.817	0.771
Histological differeniation	0.964	0.727-1.278	0.800
AFP	1.162	0.758-1.781	0.491
TPD52	0.488	0.312-0.764	0.002*	0.571	0.357-0.911	0.019*

HR, hazard ratio; CI, confidence interval; AFP, alpha-fetoprotein.

^*Statistically significant (P < 0.05).