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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Kidney Int. 2016 Apr 28;89(6):1293–1306. doi: 10.1016/j.kint.2016.02.030

Figure 1. Survival of complete MHC-mismatched renal allografts in wild type C57BL/6, B6.CCR5−/− and B6.CD8−/−CCR5−/− recipients.

Figure 1

Figure 1

Groups of wild type C57BL/6 (n = 9), B6.CCR5−/− (n = 10) and B6.CD8−/−CCR5−/− (n = 9) mice received renal allografts from A/J donors. A group of wild type C57BL/6 mice (n = 5) also received isografts. (a) Nephrectomy of the remaining native kidney was performed on day 5 post-transplant and graft survival was followed by daily examination of overall animal health. **P<0.01; ***P<0.005; when compared to survival of allografts in wild type C57BL/6 recipients. (b–d) Histological evaluation of kidney allografts from B6.CCR5−/− recipients on day 6 post-transplant stained with: (b) hematoxylin and eosin; (c) anti-C4d antibody; and (d) anti-Mac2 antibody. Arrows indicate marginating leukocytes. Images shown are representative of 3 individual allografts in the group.