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. 2016 May 17;7:124. doi: 10.3389/fphar.2016.00124

FIGURE 2.

FIGURE 2

Epoxydocosapentaenoic acids limit H/R-induced cellular oxidative stress responses. HL-1 cardiac cells were subjected to either 30 h normoxia or 24 h hypoxia and 6 h reoxygenation in the presence of 19,20-EDP (1 μM), DHA (100 μM), and/or MSPPOH (50 μM). Treatment of HL-1 cells exposed with DHA or EDPs during H/R injury did not affect generation of ROS (A), while preserved total cellular antioxidant capacity (B) and decreased accumulation of MDA (C). Values are represented as mean ± SEM; N = 3 independent experiments; ∗p < 0.05 treatment vs. normoxic control, #p < 0.05 treatment group vs. H/R control or DHA/MSPPOH.