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. 2016 Mar 1;35(10):1098–1114. doi: 10.15252/embj.201592701

Figure 5. RIBEYE KO causes a loss of synaptic vesicles in the vicinity of the active zone of photoreceptor ribbon synapses.

Figure 5

  • A, B
    Representative transmission EM pictures of RBE WT/WT (A) and RBE KO/KO (B) photoreceptor ribbon synapses (blue rectangles, area adjacent to synaptic junction used for measuring junction‐associated vesicle density [size = 200 nm × 300 nm]; black squares, area in the presynaptic cytosol used to measure cytosolic synaptic vesicles [size = 200 nm × 200 nm]).
  • C
    Average vesicle ratio expressed as vesicle numbers in the area adjacent to synaptic junctions (blue rectangle) or the cytosol (black square) normalized to RBE WT/WT.
  • D
    Average number of docked vesicles within a 150‐nm range in the vicinity of the active zone.
Data information: Statistical analyses were performed using Student's t‐test; data are presented as mean ± SEM (***P < 0.001; numbers of analyzed synapses are indicated in the bars).