Figure 3. Resting-state functional connectivity patterns between group maps of the distinct MTL subregions.

(A) First column shows the subregions defined in MTL. (B) Last column shows the between-group statistical maps, with statistical threshold set at p_corrected < 0.01, corrected by AlphaSim. Warm and blue colors indicate decreased and increased functional connectivity in aMCI subjects compared to healthy controls. Color bar is presented with z score, respectively. (C) The spatial overlap in left (a) and right (b) parahippocampal and hippocampal seeds shows all brain regions of disrupted functional connectivity in aMCI subjects compared to healthy controls. The color bar (1–7 colors) indicates disrupted connectivity maps derived from each seed. Blue color shows these regions of increased functional connectivity in aMCI subjects compared to healthy controls. Notes: aHIP, anterior hippocampus; mHIP, middle hippocampus; pHIP, posterior hippocampus; PRC, perirhinal cortex; ERC, entorhinal cortex; aPHC, anterior parahippocampal cortex; pPHC, posterior parahippocampal cortex; L, the left MTL subregional networks; R, the right MTL subregional networks.