Table 2. Comparisons of functional connectivity of the parahippocampal seeds between aMCI patients and HC subjects.
Brain region | Peak MNI coordinate |
Peak Z value | Cluster size (mm3) | ||
---|---|---|---|---|---|
x | y | z | |||
The left PHG subregional networks | |||||
(1) PRC (HC > aMCI) | |||||
R Inferior temporal gyrus | 52 | 2 | −32 | 2.89 | 723 |
(2) ERC (HC > aMCI) | |||||
L Cerebelum_4_5 | −8 | −56 | −2 | 3.31 | 752 |
R Cerebelum_4_5 | 10 | −52 | −4 | 3.92 | 721 |
(3) aPHC (HC > aMCI) | |||||
R Middle temporal gyrus | 52 | 2 | −26 | 3.67 | 1336 |
(4) pPHC (HC > aMCI) | |||||
L Inferior temporal gyrus | −62 | −36 | −14 | 3.30 | 960 |
L Middle temporal gyrus | −66 | −30 | −12 | 3.43 | 1560 |
R Middle temporal gyrus | 48 | 2 | −30 | 3.60 | 1364 |
The right PHG subregional networks | |||||
(1) PRC (HC > aMCI) | |||||
R Hippocampus | 20 | −32 | 2 | 4.43 | 792 |
R Inferior temporal gyrus | 52 | −4 | −36 | 3.62 | 984 |
L Thalamus | −14 | −34 | 2 | 3.57 | 624 |
(HC < aMCI) | |||||
L Middle occipital gyrus | −34 | −78 | 26 | −3.40 | 636 |
(2) ERC (HC > aMCI) | |||||
R Hippocampus | 28 | −30 | −6 | 3.22 | 684 |
(HC < aMCI) | |||||
L Inferior occipital gyrus | −44 | −66 | −6 | −3.37 | 682 |
(3) aPHC (HC > aMCI) | |||||
none | |||||
(4) pPHC (HC > aMCI) | |||||
R Angular gyrus | 42 | −64 | 36 | 3.66 | 680 |
L Cuneus | −20 | −58 | 26 | 3.90 | 616 |
L Precuneus | 0 | −64 | 28 | 3.09 | 776 |
R Precuneus | 10 | −50 | 34 | 3.16 | 1744 |
R Middle temporal gyrus | 60 | −32 | −8 | 3.41 | 784 |
Abbreviations: HC, healthy controls; aMCI, amnestic mild cognitive impairment; PRC, anterior perirhinal cortex; ERC, entorhinal cortex; aPHC, anterior parahippocampal cortex; pPHC, posterior parahippocampal cortex.