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. 2016 May 17;6:26130. doi: 10.1038/srep26130

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(A) Quantification of GTPase activation (n = 3) demonstrated increased CDC42 activity with KLF4 knockdown in primary human esophageal keratinocytes induced to differentiate with CaCl₂; activation of CDC42 in cells with KLF4 knockdown was abolished by treatment with recombinant WNT5A. (B) Proposed model for the regulation of squamous epithelial cell differentiation and stratification via KLF4 and WNT5A. Previously described regulators of KLF4 are indicated in gray.