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. 2016 May 17;6:26239. doi: 10.1038/srep26239

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(A) RANKL, OPG, (B) the RANKL/OPG ratio, (C) MMP9, MMP2 and (D) IL-17. **P < 0.01 versus normal; ^#P < 0.05, ^##P < 0.01 versus vehicle (n = 4 per group). (E) Synovial IL-17 concentrations showed a significant positive correlation with the RANKL and MMP9 concentrations in the normal, vehicle and CP-25-treated groups.