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. 2015 Dec 16;41(7):1803–1812. doi: 10.1038/npp.2015.348

Figure 1.

Figure 1

Effect of LY2940094 on outcomes in rodent models. (a) Extracellular levels of the monoamines serotonin (5-HT), dopamine (DA) and norepinephrine (NE) in the medial prefrontal cortex (PFC) of rat brain before and after a single oral dose of LY2940094 30 mg/kg. (Each point represents the mean±SE in three to four rats.) (b) Immobility in the rat forced-swim test (n=6–8) when dosed orally 60 min before testing (*P<0.05 compared with vehicle, Dunnett's test). (c) Number of licks of a water spout when licks were either not punished or when they were punished. Each point represents the mean+SE of data in seven to eight rats (*P<0.05 compared with vehicle, Dunnett's test). (d) The number of marbles buried by mice (n=7–8; *P<0.05, Dunnett's test). Abbreviations: 3, 10, and 30, doses of LY2940094 in mg/kg, p.o.; IMI, imipramine (positive control) 15 mg/kg, i.p, chlordiazepoxide 20 mg/kg i.p.; i.p., intraperitoneal; veh, vehicle.