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. 2015 Dec 23;41(7):1822–1830. doi: 10.1038/npp.2015.352

Figure 1.

Figure 1

Dynamic resting-state functional connectivity of medial prefrontal cortex (MPFC) in unmedicated individuals with major depressive disorder (MDD) compared with healthy controls (HC). (a) Compared to the HC group (n=109), the MDD group (n=100) exhibited decreased dynamic functional connectivity between a seed region of interest (ROI) in MPFC and regions of parahippocampal gyrus (PHG). (b) Average dynamic functional connectivity (SD in Fisher's z-transformed Pearson's correlations across a series of sliding windows) in the PHG for each group. (c) To illustrate window-by-window patterns of functional connectivity, displayed are MPFC-PHG functional connectivity values (Fisher's z-transformed Pearson's correlations) for each of the 19 sliding windows, for a single subject in the MDD group and a single subject in the HC group. (d) In comparison to the HC group, the MDD group also had increased dynamic functional connectivity between MPFC and reas of insula. (e) Average dynamic functional connectivity in the insula for each group. (f) To illustrate window-by-window patterns of functional connectivity, shown are MPFC-insula functional connectivity values for each of the 19 sliding windows, for a single subject in the MDD group and a single subject in the HC group. Note: group differences (MDD−HC) are significant at peak amplitude p<0.01, two-tailed t-test, FDR p<0.05.