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. 2016 Jan 13;41(7):1874–1887. doi: 10.1038/npp.2015.357

Figure 6.

Figure 6

Ketamine treatment activates mTOR signaling in rat prefrontal cortex (PFC). Effects of ketamine (20 mg/kg, i.p. injected 5 times once every 6 days) or saline, on phospho-Akt308, phospho-ERK, phospho-mTOR and phospho-P70S6K in the (a–d) hippocampus and (e–h) prefrontal cortex (PFC) in groups of rats fed CD or HFD for 16 weeks and who underwent behavioral testing before killing the rats (cf Figure 5). Values represent mean±SEM (n=8 animals). *P<0.05; $P=0.071, #P=0.063, ANOVA and Fisher's least significant difference post hoc test for multiple-group comparisons.