Figure 7.

P2X7 receptor antagonist reverses anxiety caused by HFD. (a) Experimental paradigm: rats were exposed to CD or HFD for 116 days, and were then administered A-804598 (5 mg/kg, i.p.) or vehicle, twice daily for the last 25 days. Behavioral tests were conducted to assess the effects of HFD and drug treatment on anxiety in the (b) novelty suppressed feeding test (NSFT), (c and d) open field test (OFT), and (e and f) elevated plus maze. (g) Neither diet nor treatment influenced locomotor activity (LMA). Results are presented as the mean±SEM, n=8 per group. *P<0.05; ^#P=0.06, ANOVA and Fisher's least significant difference post hoc test for multiple-group comparisons.