Figure 3.

Cocaine administration is associated with increased activation of GLP-1-expressing neurons in the NTS. (a) Representative images of cells in the NTS double labeled for GLP-1 (green) and c-Fos (red) are shown for rats receiving systemic 10 mg/kg cocaine or saline. Although total NTS GLP-1-positive cells (b) were not different between cocaine-treated rats and saline controls, there was significant increase in total c-Fos-positive cells (c) in the NTS of rats receiving cocaine compared with saline controls. (d) Quantification of colabeling in NTS neurons revealed that 70.4±1.42% of GLP-1-expressing neurons in the NTS are c-Fos positive in cocaine-treated rats (n=4/treatment); cc, central canal. *P<0.05. A full color version of this figure is available at the Neuropsychopharmacology journal online.