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. 2016 May 17;6:26091. doi: 10.1038/srep26091

Figure 4. AhRR-deficiency confers enhanced resistance to LPS induced shock.

Figure 4

(a) Survival curves of AhRR+/+, AhRRE/+ and AhRRE/E mice injected with 15 mg/kg LPS (n = 12–15) log-rank test **p < 0.01, AhR+/+ vs AhRRE/+ or AhR+/+ vs AhRRE/E mice. (b) Numbers of apoptotic cells were determined by TUNEL staining of liver sections n = 4–5 (c) Serum levels of TNF-α and IFN-γ in AhRR+/+, AhRRE/+, and AhRRE/E mice after LPS injection (n = 5–6). (d) Systemic production of IL-12p70, IL-1β and IL-10 after LPS injection (n = 5–6). Expression of IL-1β and TNF-α in lung (e) and liver (f) of AhRR+/+, AhRRE/+ and AhRRE/E mice that were either untreated (0 h) or treated with LPS for 3 h (n = 5–6). Data are shown as mean ± s.e.m.; significance was determined by one way ANOVA corrected for multiple comparisons by the Sidak method *p < 0.05, **p < 0.01 (AhRRE/+ or AhRRE/E vs WT).