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. Author manuscript; available in PMC: 2016 May 17.
Published in final edited form as: Science. 2014 Aug 21;346(6205):89–93. doi: 10.1126/science.1252945

Fig. 3. Restored CP function after neutralization of the age-induced type I IFN response in the brain.

Fig. 3

(A–B) ifit1, irf7 (A), and bdnf and igf1 (B) mRNA expression in CP epithelial cells cultured for 24h with murine IFN-β (n=4 per group; bars represent mean ± SEM; *, P < 0.05; ***, P < 0.001, Student’s t test). (C) ifit1 and irf7 mRNA expression in the CP 3 days after α-IFNAR or IgG control i.c.v. administration. (D–E) bdnf and igf1 (D) and ccl11 and ccl17 (E) mRNA expression in the CP 7 days after α-IFNAR or IgG control i.c.v. administration (n=6–7 per group). Throughout the figure, bars represent mean ± SEM; *, P < 0.05; **, P < 0.01; one-way ANOVA with Newmann-Kleus post-hoc test.