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. 2016 May 17;15:280. doi: 10.1186/s12936-016-1329-z

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Inhibitory effects of second-generation antidepressants on primaquine metabolism by recombinant CYP2D6. The relative per cent primaquine remining after 60-min incubations with CYP 2D6 vs antidepressent concentration is shown for each compound tested. Fluoxetine (a) and paroxetine (b) were the most potent inhibitors for CYP2D6-mediated metabolism of primaquine, while desvenlafaxine (h) was the least potent. c–g are titration curves for the remaining antidepressants tested (fluvoxamine, sertraline, escitalopram, citalopram, venlafaxine). The determined IC₅₀s are shown above each graph. The error shown is from duplicate experiments