Table 1.
List of antidepressants utilized in this study
| Antidepressant | Enzymes involved in biotransformation | Enzymes inhibited by antidepressant |
|---|---|---|
| Citalopram | CYP2C19, CYP2D6, and CYP3A4 | CYP2D6 (weak) |
| Escitalopram | CYP2C19, CYP2D6, and CYP3A4 | CYP2D6 (weak) |
| Fluoxetine | CYP2D6, CYP2C9, CYP2C19, and CYP3A4 | CYP2D6 (strong), CYP2C9 (moderate), CYP2C19, (weak to moderate), CYP3A4 (weak to moderate), CYP1A2 (weak) |
| Fluvoxamine | CYP1A2 and CYP2D6 | CYP2D6 (weak), CYP1A2 (strong), CYP2C19 (strong), CYP2C9 (moderate), CYP3A4 (moderate) |
| Paroxetine | CYP2D6 and CYP3A4 | CYP2D6 (strong), CYP1A2 (weak), CYP2C9 (weak), CYP2C19 (weak), CYP3A4 (weak) |
| Sertraline | CYP2C9, CYP2C19, CYP2D6, and CYP3A4 | CYP2D6 (weak to moderate), CYP1A2 (weak), CYP2C9 (weak), CYP2C19 (weak), CYP3A4 (weak) |
| Venlafaxine | CYP2D6 and CYP3A4 | CYP2D6 (weak) |
| Desvenlafaxine | CYP3A4 | CYP3A4 (weak) |
Shown are the enzymes responsible for metabolism of each antidepressant, and enzymes each that each molecule inhibits. Table was adapted from [22]