Fig. 2.
Low-magnification overview of immunofluorescence labeling of connexin29 (Cx29) and KV1.1 in adult rat sciatic nerve (A) and Cx29 channels in adult wild-type (WT) mouse and Cx29 knockout (ko) mouse (B and C). A: 3 images of the same field, showing similar patterns of labeling for Cx29 (A1) and KV1.1 (A2) at juxtaparanodal regions (arrows). Distinct patterns of labeling can be seen at SLIs (arrowheads), and overlapping patterns are visible along longitudinally oriented strands at internodal regions corresponding to locations of inner mesaxon (double arrows), as shown in the overlay (A3). B and C: immunofluorescence labeling of Cx29 shown in sciatic nerve of adult WT mouse (B) is absent in sciatic nerve of Cx29 ko mouse (C). Scale bars are as indicated on each lettered group of panels.