Table 1.

Thalamocortical connectivity

									Delay
Source Layer	Cell Type	Target Layer	Cell Type	Transmitter	Style	Pmax (height)	Radius or Size	Strength	Mean	SD
Optic nerve	Exc	LGN	Exc, Inh	AMPA	Gaussian	0.75	1	10	2	1
Thalamic
LGN	Exc	NRT	Exc	AMPA	Gaussian	1	2	2	2	0.25
LGN	Inh	LGN	Exc, Inh	GABAA	Gaussian	1	2	2	1	0.25
NRT	Inh	NRT	Inh	GABAA	Gaussian	0.5	12	2	1	0.25
NRT	Inh	LGN	Exc, Inh	GABAA	Gaussian	0.15	12	2	2	0.25
NRT	Inh	LGN	Exc, Inh	GABAB	Gaussian	0.05	12	2	2	0.25
M cells	Exc	M cells	Exc, Inh	AMPA, NMDA	Rectangular	0.03	10 × 10	1	2	0.25
M cells	Inh	M cells	Exc, Inh	GABAA	Gaussian	0.3	2	2.9	2	0.25
Thalamocortical
LGN	Exc	IV, Infra	Inh	AMPA	Gaussian	0.1	5	3.5	3	0.25
LGN	Exc	IV, Infra	Exc	AMPA	Rectangular	0.5	8 × 1	3.5	3	0.25
M cells	Exc	Supra, Infra	Exc, Inh	AMPA	Gaussian	0.1	12	0.3	7	0.2
Corticothalamic
Infra	Exc	NRT	Inh	AMPA	Gaussian	0.5	5	0.5	8	0.5
Infra	Exc	LGN	Exc, Inh	AMPA	Gaussian	0.25	7	0.33	8	0.5
Infra	Exc	M cells	Exc, Inh	AMPA	Gaussian	0.1	12	0.62	5	1
V1 intraareal
Supra	Exc	Supra	Exc	AMPA	Rectangular	0.064	10 × 10	1	2	0.25
Supra	Exc	Supra	Exc	NMDA	Rectangular	0.064	10 × 10	0.75	2	0.25
Supra	Exc	Supra	Inh	AMPA	Gaussian	0.05	12	0.6	2	0.25
Supra	Inh	Supra	Exc, Inh	GABAA	Gaussian	0.025	7	0.5	2	0.25
Supra	Inh	Supra	Exc, Inh	GABAB	Gaussian	0.5	2	0.5	2	0.25
IV	Exc	IV	Exc	AMPA	Rectangular	0.0384	10 × 10	1	2	0.25
IV	Exc	IV	Inh	AMPA	Gaussian	0.05	12	0.6	2	0.25
IV	Inh	IV	Exc, Inh	GABAA	Gaussian	0.025	7	0.5	2	0.25
Infra	Exc	Infra	Exc	AMPA	Rectangular	0.0384	10 × 10	1	2	0.25
Infra	Exc	Infra	Inh	AMPA	Gaussian	0.05	12	0.6	2	0.25
Infra	Exc	Infra	Exc, Inh	GABAA	Gaussian	0.025	7	0.5	2	0.25
V1 interareal
Supra	Exc	Infra	Exc, Inh	AMPA	Gaussian	1	2	1	2	0.25
Supra	Exc	Infra	Exc	NMDA	Gaussian	1	2	1	2	0.25
Supra	Inh	IV, Infra	Exc, Inh	GABAB	Gaussian	0.5	2	0.5	2	0.25
IV	Exc	Supra	Exc, Inh	AMPA	Gaussian	1	2	2.21	2	0.25
Infra	Exc	Supra	Exc, Inh	AMPA	Gaussian	1	2	2.21	2	0.25
Infra	Exc	IV	Exc, Inh	AMPA	Gaussian	1	2	2.21	2	0.25

Parameters for the connectivity profiles used to construct the thalamocortical network. Connection profiles are listed per layer and neuron type for the large-scale model. Gaussian connections are selected according to a Gaussian distribution (σ = 7.5) with a peak of P_max. Rectangular connections are selected by the maximum probability P_max within a rectangular area. The radius of the Gaussian connections and size (area) of rectangular connections are measured in no. of neurons (so 10 × 10 means a probability distribution over a square of 10 neurons). Strength (expressed in no. of simultaneous PSPs per connection) is a modifier of the synaptic currents defined in materials and methods. The mean delay of the spike impulse from the source cell to the target cells and its SD are measured in ms.

Exc, excitatory; Inh, inhibitory; Infra, infragranular; Supra, supragranular.