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. Author manuscript; available in PMC: 2016 May 17.
Published in final edited form as: Neurobiol Aging. 2014 Dec 12;36(3):1496–1504. doi: 10.1016/j.neurobiolaging.2014.12.004

Fig. 1.

Fig. 1

Predicted naked mole-rat tau amino acid sequence is highly similar to human tau. The longest human brain tau protein splice variant (4R2N) aligned to a putative NMR tau protein indicates highest conservation at the carboxy-terminus with 100% identity at the functional microtubule-binding domain. Antibody epitopes used in this study are indicated by underline and bold typeface. Abbreviations: MTBD: Microtubule Binding Domain; HT7, Tau46 and Tau5: total tau antibodies; CP13: recognizes tau phosphorylated at Ser202/Thr205; PHF1 recognizes tau phosphorylated at Ser396/404. Asterisk (*) indicates a fully conserved residue; colon (:) indicates conservation between groups of strongly similar properties; period (.) indicates conservation between groups of weakly similar properties. Amino acid numbering derived from human 4R2N splice variant.