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. Author manuscript; available in PMC: 2016 May 17.
Published in final edited form as: Neurobiol Aging. 2014 Dec 12;36(3):1496–1504. doi: 10.1016/j.neurobiolaging.2014.12.004

Fig. 6.

Fig. 6

Adult NMRs express more HT7-tau and phospho-tau than 3xTg-AD mice with overt pathology. (A) Capillary electrophoresis of 7-year-old NMR and 15-month-old 3xTg-AD brain homogenates probed for total tau (HT7) and phospho-Ser202/Thr205 tau (CP13). (B) Corresponding densitometry indicates that NMRs express significantly higher HT7 total tau (***: unpaired t-test, p < 0.0001) and pSer202/Thr205 (**: unpaired t-test, p = 0.0025). (C) IHC with hippocampal tissue from representative NMR and 3xTg-AD mice revealed that NMRs maintain axonal tau expression in the mossy fibers but 3xTg-AD do not (CA3 inset, arrow points to mossy fibers). Instead tau from 3xTg-AD mice has inappropriately accumulated in neuronal soma and dendrites (CA1 inset).