Figure 3.

Apparent effect of tumor necrosis factor blockade on latent tuberculosis infection (left) and total number of active tuberculosis cases (right), based on hidden Markov modeling and Monte Carlo simulation. Colored shading indicate 95% confidence intervals. Latent TB infection is defined functionally by its capacity to reactivate. The hatched area (right) indicates TB cases arising due to new infection, which occur equally for both agents. Adapted from (Wallis, 2008), with permission.