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TOP1210 is a potent inhibitor of an adaptive immune response in anti-CD3/anti-CD28–stimulated T-cell release of IFN-γ (A) and IL-2 (B). Both TOP1210 and dasatinib inhibit IFN-γ release with similar potency, whereas TOP1210 is approximately 15-fold weaker than dasatinib as an inhibitor of IL-2 release. BAY61-3606 demonstrates weaker inhibition, whereas BIRB-796 has little-to-no effect. Graphs represent means of at least 3 independent experiments ± SEM.
