Fig. 10.

A timecourse of A expression alongside metabolomic correlates of experimental phentoypes. The timecourse of Aβ expression (A) is plotted alongside consequent experimental phenotypes (B–E). The increasing sensitivity of the flies to Aβ toxicity at day 15 (B) was closely correlated in time with sensitivity to an oxidative stressor in control flies (C, control). The presence of Aβ brings forward the onset of oxidative sensitivity (C, Aβ42). Thermal destabilization of dynamin, as a marker of proteostasis, occurs gradually with age across this timecourse (D). Aβ expression did not further functionally destabilize dynamin (E). Metabolic markers for A–D are presented (right column, ↑ = increase, ↓ = decrease). Metabolites that did not change with time (E) were not considered informative. Abbreviation: Aβ, amyloid beta.