Fig. 6.

The expression of Aβ causes a shift in the age-related changes in fly metabolomes. The figure shows score plots for principal components 2 and 3 for all head (A) and body (B) samples. The metabolomic trajectories are indicated by colored lines (open circles for days 0 and 8; closed circles for days 14, 18, 21, 24, 30, and 40; A42 Arctic flies (red) lived only until day 26 which is their last sampling point). For clarity, error bars showing the standard deviation are presented for the 51D control flies only. The error bars for all other points were of a similar magnitude. Abbreviation: Aβ, amyloid beta.