Fig. 8.

Summary of NMR spectral changes induced by the expression of A40/Aβ42 and Aβ42 Arctic. The figure provides an overview of the metabolomic changes induced by Aβ-expression. Positive and negative signals represent the increases and decreases in metabolite concentrations. Significant alterations were color coded from blue to red, with red representing the highest correlation between metabolite and genotype. Panels A and B compare the spectral changes between the 51D control and Aβ40/Aβ42 samples (comparing controls with nontoxic A expression), whereas panels C and D compare the changes between Aβ40/Aβ42 and Aβ42 Arctic flies (comparing non-toxic with toxic-A expression). Abbreviations: Aβ, amyloid beta; NMR, nuclear magnetic resonance.