Serum MMP9 in normal ageing and Werner syndrome from both sexes. Non-linear regression model used in this analysis was expressed as MMP9 = exp (a + b*Age + c*Sex), where a, b, and c are estimated regression coefficients. Estimated regression coefficient and p values for age and sex are inserted in the right table next to the figure for comparison. ○: Normal Male (dotted line; n = 91), ●: Normal Female (dotted line; n = 126), □: WS Male (solid line; n = 24), ■: WS Female (solid line; n = 17).