Table 1. Metabolic effects of viral infections.
Virus | Metabolic effect | Ref. |
---|---|---|
VACV, DENV | Alteration of glycolysis, FAS, and glutaminolysis | (15) |
HCMV | de novo pyrimidine biosynthetic flux in host cells | (4) |
HCMV, influenza A | Inhibition of FAS, suppression of replication HCMV and influenza A | (27) |
HCMV | Infection requirement of long chain FA metabolism: acyl-CoA synthetases and fatty acid elongases | (18) |
KSHV | Inhibition of FAS and decrease in number of lytic enveloped viruses, induced apoptosis infected cells | (10) |
EBV, VZV, poliovirus, HCV | Inhibition of FAS, lower number of infectious virus | (2,32–35) |
This table summarizes the main effects that viral infections have over metabolism. VACV: vaccinia virus; DENV: Dengue virus; HCMV: Human Cytomegalovirus; KSHV: Kaposi's Sarcoma-associated herpesvirus; EBV: Epstein-Barr virus; HCV: Hepatitis C virus; FA: Fatty Acids; FAS: Fatty Acids Synthesis; TCA: tricarboxylic acid cycle.