Table 4.

Change in the quality of life as measured by NEI-VFQ-25²⁰ and EQ-5D³⁹

Parameters	Baseline, mean (SD)	3 months, mean (SD)	Change in 0–3 months, mean (SD)	P-value	6 months, mean (SD)	Change in 0–6 months, mean (SD)	P-value
Vision-related quality of life
NEI-VFQ-25 composite	84.8±14.5	87.8±11.9	3.04±6.98	0.005	89.3±11.5	3.58±7.11	0.002
Effect size				0.23			0.34
Subscales
General health	62.2±23.6	60.6±19.6	−1.7±17.8	0.538	58.9±19.3	−3.3±17.4	0.204
General vision	70.2±19.4	74.2±17.9	4.0±13.9	0.060	76.0±15.7	3.1±14.7	0.164
Ocular pain	84.2±16.1	86.4±16.0	2.2±14.7	0.315	87.8±14.0	3.6±13.5	0.079
Near activities	80.6±21.5	83.1±19.0	2.3±11.9	0.151	87.5±18.9	5.6±10.3	0.001
Effect size							0.34
Distance activities	85.3±18.2	88.2±16.1	3.0±8.7	0.028	89.0±16.9	3.7±10.0	0.017
Effect size				0.17			0.28
Social functioning	93.3±915.2	95.3±11.7	1.9±8.4	0.128	95.6±11.0	1.9±7.5	0.090
Mental health	80.0±21.3	86.3±12.5	6.3±14.7	0.006	87.1±14.8	5.3±11.5	0.003
Effect size				0.36			0.39
Role difficulties	80.3±22.4	84.2±20.5	3.9±19.7	0.193	86.7±19.1	5.3±17.0	0.043
Dependency	94.6±15.0	95.2±11.0	0.6±10.7	0.730	95.9±10.1	0.6±9.6	0.701
Driving	90.3±17.0	92.7±16.0	2.3±8.2	0.166	93.0±16.3	3.3±9.0	0.076
Color vision	93.3±16.3	95.0±12.6	1.7±15.4	0.473	97.2±9.6	2.2±14.9	0.323
Peripheral vision	85.6±23.5	90.6±16.2	5.0±16.5	0.048	90.6±16.2	5.0±18.2	0.071
Effect size				0.25
Quality of life – overall health score index
EQ-5D	0.89±0.13	0.89±0.13	0.005±0.083	0.706	0.92±0.13	0.032±0.096	0.034
Effect size							0.23

Notes: Results are in response to an analysis of variance; significant P-values are those <0.05.

Abbreviation: EQ-5D, EuroQoL-5 dimension.