Figure 1.
Plasma and glomerular C3 in mice with combined deficiency of factor h (FH) and complement receptor 3. (a,b) Plasma C3 levels (a) and glomerular C3 staining intensity (b) in 8-month-old Cfh–/–.Itgam–/–, Cfh–/–, and Itgam–/– mice housed in specific-pathogen free conditions. Horizontal bars denote median values. AFU, arbitrary fluorescent units. (c) Representative images of glomerular C3 immunostaining in the 3 genotypes. Bar = 80 μm. Each symbol represents a mouse. P values derived from Dunn’s multiple comparison test.