Figure 2.

Bone marrow transplantation in factor H (FH)–deficient mice. Two- to three-month-old Cfh^–/– mice were reconstituted with bone marrow (BM)–derived cells isolated from Itgam^–/–, wild-type, or Cfh^–/– mice and the spontaneous renal phenotype assessed at 8 months of age. Plasma urea (a), glomerular cellularity score (b), and glomerular macrophage score (c) were significantly higher in Cfh^–/– mice reconstituted with Itgam^–/– BM-derived cells. Horizontal bars denote median values. Each symbol represents a mouse. P values derived from Dunn’s multiple comparison test.