Table 1.
Spontaneous renal disease in FH-deficient mice with or without CR3
| Specific pathogen–free conditions | Non–specific pathogen–free conditions | |||
|---|---|---|---|---|
| Genotype | Cfh–/–.Itgam–/– | Cfh–/– | Cfh–/–.Itgam–/– | Cfh–/– |
| Mice, number/sex | 10/F | 5/F | 12/F | 12/F |
| Survival at 8 months, % (number) | 90% (9) | 100% (5) | 50% (6)c | 100% (12) |
| Plasma urea, median mmol/l (range) | 13.3 (9.8–44.5) | 11.5 (7.3–15.1) | 13.5 (10.1–39.2)d | 12.9 (9.7–25.7) |
| Glomerular cell count, median (range) | 53.4 (40.8–75.9)a | 36.6 (34.9–44.4) | 44.2 (39.2–61.7)d | 41.7 (35.9–56.1) |
| Glomerular macrophage count, median (range) | 4.3 (0.9–9.9) | 1.9 (1.2–3.1) | 8.5 (5.1–14.5)b,d | 3.7 (0.9–11.0) |
F, female.
a
P = 0.003. bP = 0.0007, Mann-Whitney Test. cP = 0.006, log-rank test. dData refer to the 6 mice that were culled at the 8-month time point.