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. 2016 May 10;9:2795–2803. doi: 10.2147/OTT.S98991

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© 2016 Fan et al. This work is published and licensed by Dove Medical Press Limited

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Silencing of CPE decreases the invasive and migratory properties of osteosarcoma cells.

Notes: (A, B) Cell mobility of MG-63 cells, control shRNA cells, and CPE shRNA cells was determined by wound healing assay, and the migration rates at 12 and 24 hours were calculated. (A) Magnification 100×, scale bars =100 μm. (C, D) Cell invasive ability was assessed by Matrigel invasion assay, and the invaded cells were counted under the microscope after 24 hours incubation. (C) Magnification 200×, scale bars =50 μm. Data are expressed as the mean ± standard deviation of triplicate experiments. Compared with the control group, ^*P<0.05, ^**P<0.01.

Abbreviations: CPE, carboxypeptidase E; shRNA, short hairpin ribonucleic acid.