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(A) Degradation curves of FD and SPIO-PEG-D over 114 hours. (B) DNA interstrand crosslinking in HT-29 cells after treatment with FD or SPIO-PEG-D for 24 hours. (C) Viability of HT-29 cells after incubation with FD, SPIO-PEG-D, or SPIO-PEG-D/MF (mean ± SD) (n=5).
Abbreviations: FD, free doxorubicin; SPIO-PEG-D, superparamagnetic iron oxide with polyethylene glycol conjugated with doxorubicin; SPIO-PEG-D/MF, SPIO-PEG-D under magnetic field; SD, standard deviation.
