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. 2016 May 12;11:2021–2037. doi: 10.2147/IJN.S94139

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© 2016 Liang et al. This work is published and licensed by Dove Medical Press Limited

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In vivo MR imaging and detection of SPIO-PEG-D.

Notes: (A) T₂-weighted MR images before and after treatment with SPIO-PEG-D (green arrows) or SPIO-PEG-D/MF (red arrows) and (B) MR signal intensity in mouse tumors (mean ± SD) (n=8). (C) Confocal laser scanning microscopic images of Dox in tumor tissues and microscope images of Prussian blue dye-stained tumor tissues after treatment with SPIO-PEG-D and SPIO-PEG-D/MF at 24 hours. Circled regions show the deposition of SPIO-PEG-D. (D) TEM image of tumor tissues after treatment with SPIO-PEG-D/MF. Black arrow indicates SPIO-PEG-D deposition.

Abbreviations: MR, magnetic resonance; SPIO-PEG-D, superparamagnetic iron oxide with polyethylene glycol conjugated with doxorubicin; SPIO-PEG-D/MF, SPIO-PEG-D under magnetic field; SD, standard deviation; Dox, doxorubicin; TEM, transmission electron microscope.