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. 2016 May 12;11:2021–2037. doi: 10.2147/IJN.S94139

Figure 12.

Figure 12

Tumor growth inhibition test of sc HT-29 xenografts in BALB/c nude mice.

Notes: (A) Mice were IV injected with SPIO-PEG-D at a dose of 2.5 mg/kg Dox. The administration was carried out seven times with a 3-day interval (arrows: treatment days). (B) Body weight changes of the tumor-bearing mice. (C) TUNEL analysis of different tissue sections from the tumor-bearing mice treated with different therapeutics at a dose of 2.5 mg/kg Dox on day 40 after HT-29 cell implantation. The administration was carried out seven times with a 3-day interval. Green: apoptotic cells show green fluorescence (mean ± SD [n=4]. *P<0.05 and **P<0.01).

Abbreviations: sc, subcutaneous; IV, intravenous; SPIO-PEG-D, superparamagnetic iron oxide with polyethylene glycol conjugated with doxorubicin; Dox, doxorubicin; TUNEL, terminal deoxynucleotidyl transferase dUTP nick-end labeling; SD, standard deviation; FD, free doxorubicin; SPIO-PEG-D/MF, SPIO-PEG-D under magnetic field.