Figure 9.

Cellular uptake of SPIO-PEG-D with or without magnetic field.

Notes: (A) T₂-weighted MR phantom images of HT-29 cells after incubation with SPIO-PEG-D or SPIO-PEG-D/MF for 3, 6, or 24 hours and (B) Prussian blue staining images of HT-29 cells after 24-hour treatment with SPIO-PEG-D and SPIO-PEG/MF. (C) The iron uptake in HT-29 cells treated with 100 µg Fe/mL of SPION-PEG-D after treatment with SPIO-PEG-D and SPIO-PEG/MF at different incubation time (mean ± SD) (n=5). **P<0.01.

Abbreviations: MR, magnetic resonance; SPIO-PEG-D, superparamagnetic iron oxide with polyethylene glycol conjugated with doxorubicin; SPIO-PEG-D/MF, SPIO-PEG-D under magnetic field; SPIO-PEG/MF, SPIO-PEG under magnetic field; SPION-PEG-D, SPIO nanoparticle with PEG conjugated with doxorubicin; SD, standard deviation; SPION-PEG-D/MF, SPION-PEG-D under magnetic field.