Table 3.
Associations Between Biochemical Markers and Pruritus Scores and Their Ability to Differentiate ICP From PG
| Biomarker | Association With Pruritus | |||||
|---|---|---|---|---|---|---|
| ICP | PG | Ability to Identify ICP | ||||
| Change in VAS (95% CI) | P | Change in VAS (95% CI) | P | OR (95% CI) | P | |
| PM3S | 6.1 (0.6‐11.5) | 0.03 | 0.9 (−4.6–6.3) | NS | 1.7 (1.1‐2.4) | 0.01 |
| PM3DiS | 2.2 (−1.6–6) | NS | −2.5 (−6.2–1.2) | NS | 2.1 (1.4‐3.4) | <0.01 |
| PM2DiS | −0.3 (−5.3–4.6) | NS | −8.0 (−14.9–1.2) | 0.03 | 1.7 (1.2‐2.5) | 0.01 |
| Autotaxin | 1.4 (0.3‐2.4) | 0.01 | 2.0 (−0.1–4.1) | NS | 2.3 (2.1‐2.6) | <0.01 |
Linear regression results showing the effect of doubling biochemical markers and change in visual analogue score for ICP and PG and ORs for developing ICP. P value shown where a comparison resulted in statistical significance.
Abbreviations: NS, not significant; VAS, visual analogue score.