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DDB1–VPRBP targets substrates to distinct E3 ubiquitin ligase complexes. The DDB1–VPRBP heterodimer can target different substrate to a DYRK2–HECT or a Cul4–ROC1 E3 ligase complex. DYRK2 is required for assembly of the E3 complex and for phosphorylation of its substrate katanin, but not for the initial binding of katanin with VPRBP. Ub, ubiquitin.
