Table 2.
Top 30 genes differentiating ECR and non-ECR papillary thyroid cancers
| Gene | ECR/non-ECR expression microarray | ECR/non-ECR 3-ANOVA | ECR/non-ECR exon microarray | ECR/non-ECR qPCR | |||||
|---|---|---|---|---|---|---|---|---|---|
| Symbol | Description | FDR | Fold change | P value | FDR | FDR | Fold change | FDR | Fold change |
| USP27X | Ubiquitin-specific peptidase 27, X-linked | 0.00516 | 1.34 | 0.0000093 | 0.05 | NS | ND | ||
| ANKS6 | Ankyrin repeat and sterile alpha motif domain containing 6 | 0.0103 | 1.34 | 0.0000152 | 0.05 | 0.058 | 1.35 | ND | |
| GPX7 | Glutathione peroxidase 7 | 0.0103 | 0.61 | 0.0000007 | 0.019 | 9 | NS | ||
| MNT | MAX binding protein | 0.0187 | 1.28 | 0.0000031 | 0.04 | 0.058 | 1.22 | NS | |
| PPP1R9A | Protein phosphatase 1, regulatory (inhibitor) subunit 9A | 0.0341 | 1.5 | 0.0000137 | 0.05 | NS | 0.021 | 1.225 | |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.0341 | 1.29 | 0.000114 | 0.094 | 0.133 | 1.22 | NS | |
| DDR1 | Discoidin domain receptor tyrosine kinase 1 | 0.0341 | 1.34 | 0.000353 | NS | 0.070 | 1.33 | ND | |
| HNRNPUL2 | Heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0341 | 1.25 | 0.0000225 | 0.053 | 0.070 | 1.08 | ND | |
| GNL1 | Guanine nucleotide binding protein-like 1 | 0.0341 | 1.23 | 0.000235 | NS | 0.101 | 1.12 | ND | |
| PTCD3 | Pentatricopeptide repeat domain 3 | 0.0341 | 0.8 | 0.0000205 | 0.053 | NS | ND | ||
| ZBTB43 | Zinc finger and BTB domain containing 43 | 0.0341 | 1.4 | 0.000068 | 0.09 | NS | ND | ||
| CIC | Capicua homologue (Drosophila) | 0.0341 | 1.26 | 0.0000521 | 0.09 | NS | 0.008 | 1.221 | |
| GMEB2 | Glucocorticoid modulatory element binding protein 2 | 0.0341 | 1.26 | 0.000213 | NS | 0.070 | 1.18 | ND | |
| ZBTB7C | Zinc finger and BTB domain containing 7C | 0.0341 | 1.44 | 0.00015 | NS | 0.148 | 1.22 | ND | |
| KIAA0182 | KIAA0182 | 0.0341 | 1.32 | 0.000311 | NS | 0.123 | 1.14 | ND | |
| GNA11 | Guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | 0.0341 | 1.25 | 0.000112 | 0.094 | 0.130 | 1.22 | NS | |
| HDAC11 | Histone deacetylase 11 | 0.0341 | 1.47 | 0.000071 | 0.09 | 0.114 | 1.20 | 0.004 | 1.247 |
| SPATA2L | Spermatogenesis associated 2-like | 0.0341 | 1.26 | 0.000695 | NS | NS | ND | ||
| SLC25A23 | Solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 23 | 0.0341 | 1.41 | 0.000126 | NS | 0.090 | 1.31 | ND | |
| TIA1 | TIA1 cytotoxic granule-associated RNA binding protein | 0.0341 | 0.73 | 0.0000142 | 0.05 | NS | ND | ||
| PALM3 | Paralemmin-3 | 0.0341 | 3.42 | 0.000182 | NS | 0.136 | 1.17 | NS | |
| LYPLA2 | Lysophospholipase II | 0.0341 | 1.23 | 0.000138 | NS | NS | ND | ||
| MOB2 | Mps one binder kinase activator-like 2 | 0.0341 | 1.22 | 0.000189 | NS | NS | ND | ||
| HDGF | hepatoma-derived growth factor (high-mobility group protein 1-like) | 0.0349 | 1.19 | 0.0000155 | 0.05 | 0.070 | 1.13 | 0.021 | 1.275 |
| GOPC | Golgi-associated PDZ and coiled-coil motif containing | 0.0359 | 1.36 | 0.0000616 | 0.09 | NS | ND | ||
| JUB | Jub, ajuba homolog (Xenopus laevis) | 0.0359 | 1.39 | 0.000181 | NS | 0.093 | 1.25 | NS | |
| CTBP2 | C-terminal binding protein 2 | 0.0359 | 1.29 | 0.000171 | NS | NS | ND | ||
| EHMT2 | Euchromatic histone-lysine N-methyltransferase 2 | 0.0362 | 1.27 | 0.00011 | 0.094 | 0.101 | 1.17 | ND | |
| RAD51AP1 | RAD51 associated protein 1 | 0.0362 | 0.58 | 0.000218 | NS | 0.100 | 0.86 | 0.021 | 0.553 |
| SPRYD3 | SPRY domain containing 3 | 0.0362 | 1.3 | 0.000672 | NS | 0.075 | 1.32 | ND | |
FDR false discovery rate, ND not determined, NS not significant