Table 3.

The gene signature of exposure to Chernobyl radiation: analysis of putative confounding factors. First, four different three-way analyses were performed (with series-related subgroups) for interaction with age at diagnosis, presence of the BRAF or RET/PTC alteration, and solid histoarchitecture. For each of the analysed factors, the number of genes significant at p < 0.001 is shown in Supplementary Table S4. A final analysis performed for the three factors with the strongest effect and two series of examinations, which included exposure to Chernobyl radiation, BRAF mutation, and pathology (with subdivision into two groups, one including the classic and follicular variants, and the other both specified subgroups with solid appearance) is shown

Effect	No of probe sets at p < 0.001	No of probe sets at FDR <10 %
Exposure to Chernobyl radiation	196	33
BRAF mutation	183	114
Pathology (classical and follicular/solid component)	32	0