Table 4.

Schirmer’s test without 0.5% proparacaine anesthesia (mm/5 minutes) given as mean ± standard deviation

Visit	Placebo group	Treatment group	P-valuea
Visit 1 (day 0)	7.11±5.64	6.58±4.81	0.638
Visit 2 (week 4)	8.00±6.42	7.63±5.56	0.772
Visit 3 (week 8)	5.72±3.80	7.79±4.50	0.027
Visit 4 (week 12)	6.48±5.52	7.95±7.32	0.302
Visit 5 (week 16)	7.13±4.43	8.60±5.42	0.177
P-valueb	0.487	0.729

Notes:

^aLinear mixed model;

^brepeated-measures analysis of variance.