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. 2015 Jul 31;282(19):3669–3680. doi: 10.1111/febs.13378

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© The Authors. FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Protein group modification via SUMO. In response to specific cellular or external stimuli, the activity and localization of the SUMO conjugation machinery is altered, leading to SUMOylation of target proteins with similar functions during the cellular response. This protein group modification triggers the formation of larger protein complexes via specific SUMO–SIM interactions. Increased activity of SUMO proteases reverses this process, leading to disassembly of these protein complexes.