Table 1. Ft LVS-based live attenuated vaccines.
| Vaccine strain (Ft LVS) | Growth medium | Animal model | Sex | Vaccine dose (route) | Ft LVS challenge % protection (dose, route) | Ft SchuS4 challenge % protection (dose, route) | References |
|---|---|---|---|---|---|---|---|
| Ft LVS | MHB | C57BL/6 | F | 100 CFU (IN) | ND | 100% (25 CFU, IN) | 131 |
| SodB | MHB | C57BL/6 | M/F | 1,200 CFU (IN) | 100% (1.2×106 CFU, IN) | 40% (103 CFU, IN) | 56 |
| ClpB | BHI CDM | C57BL/6 | F | 5×104 CFU (IN) | 100% (5×103 CFU, IN) | 10% (30 CFU, IN) | 132 |
| emrA1 | MHB | C57BL/6 | F | 106 CFU (IN) | 100% (107 CFU, IN) | 15% (17 CFU, IN) | 87 |
| CapB | MHB | BALB/c | F | 106 CFU (IN) | ND | 100% (10 LD100, aerosol) | 133 |
| clpB | NA | BALB/c | NA | 5×104 CFU (IN) | ND | 30% (86 CFU, IN) | 134 |
| dsbA | McLeod | BALB/c | F | 106 CFU (SC) | ND | 100% (100 CFU, SC) 50% (100 CFU, IN) | 135 |
| wbtA | CHAH | BALB/c | M | 1.5×107 CFU (IN) | 100% (25 LD, IN) | 25% (10 CFU, IN) | 136 |
| Wzy | MHB | BALB/c | M | 2.4×107 CFU (IN) | 100% (1.2×105 CFU, IN) | 84% (8 CFU, IN) | 137 |
Abbreviations: Ft, Francisella tularensis; LVS, live vaccine strain; MHB, Mueller Hinton Broth; F, female; ND, not determined; IN, intranasal; M, male; BHI, brain heart infusion; CDM, Chamberlain's defined medium; NA, not available; SC, subcutaneous; CHAH, cysteine heart agar containing 2% hemoglobin; LD50, median lethal dose; LD100, absolute lethal dose.