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. Author manuscript; available in PMC: 2016 May 17.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2011 Feb 16;3(5):588–605. doi: 10.1002/wsbm.138

Figure 4.

Figure 4

Diffusible factor model. An upstream signal (a; blue), such as Wg in the eye, induces a proportional expression of a diffusible factor X (gray). (b) In wild type, factor X distributes in a gradient (green) whose slope determines polarity (arrows). (c) In clones that do not respond to the upstream signal, the factor X expression profile results in a distribution profile (green) with slope reversal, causing polarity reversal distal to the clone (red arrow). (d) Clones with augmented response to the upstream factor result in a distribution profile showing polarity reversal on the proximal side of the clone. (e) Factor X and factor Z signaling scheme.