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. Author manuscript; available in PMC: 2016 May 17.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2011 Feb 16;3(5):588–605. doi: 10.1002/wsbm.138

Figure 8.

Figure 8

Global signaling paradigms tested by the Amonlirdviman et al. model[71]. (a) Non-globally varying, constant slope within each cell, as suggested by the global signaling model depicted in Figure 5 (top). (b) Globally varying, uniform within each cell, similar to that proposed by Lawrence et al.[74]. (c) Globally varying, constant slope. This signal can be viewed as a combination of the forms shown in (a) and (b). Depending on whether the intercellular or intracellular components predominate, the slope can be in either direction. As shown, the subcellular asymmetry dominates, as in (a).