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. Author manuscript; available in PMC: 2016 Sep 23.
Published in final edited form as: Nature. 2016 Mar 23;532(7599):394–397. doi: 10.1038/nature17631

Figure 1. Thapsigargin induced IL-6 production is dependent on NOD1 and NOD2.

Figure 1

(a–c) BMDM from Nod1/2−/− mice and wild type littermates (n = 8) were stimulated with thapsigargin (a and b) and/or KIRA6 (c) and Il6 mRNA expression (a) and IL-6 protein synthesis (b and c) were measured. (d and e) Nod1/2−/− mice and wild type littermates (n = 7) were injected with thapsigargin and IL-6 production in the serum (d) and Il6 mRNA expression in the spleen (e) were determined. Data are presented as mean ± s.e.m.