Extended Data figure 3. Proinflammatory responses induced by thapsigargin are NOD1/2-dependent.

(a–c) Groups (n = 5) of wild-type mice and Nod1/2^−/− mice were treated with thapsigargin and received either vehicle control of TUDCA. Synthesis of IL-6 (a), KC (b) and MIP-1β (c) in the serum was determined using a Bio-plex cytokine assay. (d and e) Wild-type (C57BL/6) mice and Nod1/2^−/− mice (n = 4) were treated with thapsigargin and transcript levels of Il6 determined by quantitative real-time PCR. Data are expressed as fold-increases over vehicle control-treated animals. Data are presented as mean ± s.e.m.