. 2016 May 17;77(3):393–404. doi: 10.15288/jsad.2016.77.393

Table 3.

ADH gene variants, religious involvement, and associations with maximum drinks and dependence symptoms

Marker	Maximum drinks						Alcohol dependence symptoms
	Main effect of variant^b		Main effect of environment^b		Variant × Environment^c		Main effect of variant^b		Main effect of environment^b		Variant × Environment
	b	p	b	p	b	p	b	p	b	p	b	p
ADH1B
rs1229984^a	-3.361	<.0001	-2.040	<.0001	-0.026	.9536	-0.705	<.0001	-0.363	<.0001	0.067	.4363
rs2066702^a	-1.638	.0150	-2.072	<.0001	1.442	.0197	-0.242	.0317	-0.365	<.0001	0.269	.0045
ADH1C
rs698	0.367	.0700	-2.054	<.0001	-0.394	.0328	0.075	.0385	-0.367	<.0001	-0.110	.0010
ADH4
rs1042364	0.352	.1146	-2.055	<.0001	-0.653	.0021	0.063	.1106	-0.365	<.0001	-0.130	.0005
rs1800759	0.299	.1208	-2.053	<.0001	0.088	.6173	0.053	.1320	-0.367	<.0001	0.057	.0699

Notes: Significant effects (p < .05) are in bold, and all models controlled for age, gender, genetic ancestry using principal components, and religious affiliation.

^{^a}

ADH1B variants were coded yes/no for carrier of the minor allele; all other variants were coded additively based on the minor allele count;

^{^b}

main effects are from models including each main effect and control variables;

^{^c}

interaction effects are from models including each main effect, their interaction term, and control variables.