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. 2016 May 17;77(3):393–404. doi: 10.15288/jsad.2016.77.393

Table 3.

ADH gene variants, religious involvement, and associations with maximum drinks and dependence symptoms

graphic file with name jsad.2016.77.393tbl3.jpg

Marker Maximum drinks
Alcohol dependence symptoms
Main effect of variantb
Main effect of environmentb
Variant × Environmentc
Main effect of variantb
Main effect of environmentb
Variant × Environment
b p b p b p b p b p b p
ADH1B
 rs1229984a -3.361 <.0001 -2.040 <.0001 -0.026 .9536 -0.705 <.0001 -0.363 <.0001 0.067 .4363
 rs2066702a -1.638 .0150 -2.072 <.0001 1.442 .0197 -0.242 .0317 -0.365 <.0001 0.269 .0045
ADH1C
 rs698 0.367 .0700 -2.054 <.0001 -0.394 .0328 0.075 .0385 -0.367 <.0001 -0.110 .0010
ADH4
 rs1042364 0.352 .1146 -2.055 <.0001 -0.653 .0021 0.063 .1106 -0.365 <.0001 -0.130 .0005
 rs1800759 0.299 .1208 -2.053 <.0001 0.088 .6173 0.053 .1320 -0.367 <.0001 0.057 .0699

Notes: Significant effects (p < .05) are in bold, and all models controlled for age, gender, genetic ancestry using principal components, and religious affiliation.

a

ADH1B variants were coded yes/no for carrier of the minor allele; all other variants were coded additively based on the minor allele count;

b

main effects are from models including each main effect and control variables;

c

interaction effects are from models including each main effect, their interaction term, and control variables.